Mike Makrigiorgos, PhD, Ross Berbeco, PhD and Wil Ngwa, PhD
Image-guided small animal irradiator laboratory
Supports preclinical research:
- Nanoparticles
- Advanced biomaterials
- Immunotherapy
- Radiation sensitizers
- Liquid biopsy
Herter-Sprie Nature Comm 2014, Ngwa Phys Med Biol 2012, …
Ross Berbeco, PhD
Vascular-targeted high Z nanoparticles
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Clinical radiation therapy
Tumor vascular disruption
Improved survival
Kunjachan ACS Nano (Accepted), Kunjachan Nano Letters 2015, Berbeco IJROBP 2011,…
Funding: NIH/NCI R21, NIH/NCI R03 , JCRT Foundation,…
G. Mike Makrigiorgos, PhD
Goal: Eliminate “normal” DNA and detect mutated DNA and minimal residual disease in blood
Novel PCR-based enrichment techniques:
CoLD-PCR (Li Nature Medicine 2008)
Ice-CoLD-PCR (Milbury Nucleic Acid Res 2010)
NaME-PrO (Song Nucleic Acid Res 2016; Ladas Nucleic Acid Res 2018)
Funding: NIH/NCI R33 CA217652; NIH/NCI R01 CA221874; Bridge Foundation; and IMAT Program of the NCI, 1998-2018
Wil Ngwa, PhD
Ngwa IJROBP 2017, Boateng BJR 2017, Sinha IJROBP 2015, …
Funding: R01CA239042-01, NIH/NCI K01CA172478, JCRT Foundation Grant, Brigham Research Institute, etc.
Piotr Zygmanski, PhD
High spatial resolution (nm-mm) ultrafast (s) with full electromagnetic coupling
High precision calculations of nanodosimetry
Gadou Nanomedicine 2018, Gadou Nanomedicine 2017, Zygmanski BJR 2016,…
Ross Berbeco, PhD
Novel nanoparticles for MRI contrast and radiation dose enhancement
Gd-only and Bi-Gd nanoparticles
Preclinical work in Boston
Phase 1 clinical trial finishing in France
Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …
Funding: JCRT Foundation Grant, Brigham Research Institute
Wil Ngwa, PhD
Ngwa Nature Rev Cancer 2018, Ngwa Front Oncol 2017, Hao Phys Med Biol 2016, …
Funding: NIH/NCI R21CA205094, JCRT Foundation Grant
Robert Cormack, PhD
Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …
Funding: JCRT Foundation Grant, Brigham Research Institute