Mike Makrigiorgos, PhD, Ross Berbeco, PhD and Wil Ngwa, PhD
Image-guided small animal irradiator laboratory
Supports preclinical research:
- Nanoparticles
- Advanced biomaterials
- Immunotherapy
- Radiation sensitizers
- Liquid biopsy
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Herter-Sprie Nature Comm 2014, Ngwa Phys Med Biol 2012, …
Ross Berbeco, PhD
Vascular-targeted high Z nanoparticles
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Clinical radiation therapy
Tumor vascular disruption
Improved survival
Kunjachan ACS Nano (Accepted), Kunjachan Nano Letters 2015, Berbeco IJROBP 2011,…
Funding: NIH/NCI R21, NIH/NCI R03 , JCRT Foundation,…
G. Mike Makrigiorgos, PhD
Goal: Eliminate “normal” DNA and detect mutated DNA and minimal residual disease in blood
Novel PCR-based enrichment techniques:
CoLD-PCR (Li Nature Medicine 2008)
Ice-CoLD-PCR (Milbury Nucleic Acid Res 2010)
NaME-PrO (Song Nucleic Acid Res 2016; Ladas Nucleic Acid Res 2018)
Funding: NIH/NCI R33 CA217652; NIH/NCI R01 CA221874; Bridge Foundation; and IMAT Program of the NCI, 1998-2018
Wil Ngwa, PhD
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Ngwa IJROBP 2017, Boateng BJR 2017, Sinha IJROBP 2015, …
Funding: R01CA239042-01, NIH/NCI K01CA172478, JCRT Foundation Grant, Brigham Research Institute, etc.
Piotr Zygmanski, PhD
High spatial resolution (nm-mm) ultrafast (s) with full electromagnetic coupling
High precision calculations of nanodosimetry
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Gadou Nanomedicine 2018, Gadou Nanomedicine 2017, Zygmanski BJR 2016,…
Ross Berbeco, PhD
Novel nanoparticles for MRI contrast and radiation dose enhancement
Gd-only and Bi-Gd nanoparticles
Preclinical work in Boston
Phase 1 clinical trial finishing in France
Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …
Funding: JCRT Foundation Grant, Brigham Research Institute
Wil Ngwa, PhD
![](https://medicalphysics.bwh.harvard.edu/wp-content/uploads/2019/02/Bio7-1-e1549558561704.png)
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Ngwa Nature Rev Cancer 2018, Ngwa Front Oncol 2017, Hao Phys Med Biol 2016, …
Funding: NIH/NCI R21CA205094, JCRT Foundation Grant
Robert Cormack, PhD
Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …
Funding: JCRT Foundation Grant, Brigham Research Institute