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Small Animal Radiation Research Platform

Mike Makrigiorgos, PhD, Ross Berbeco, PhD and Wil Ngwa, PhD

Image-guided small animal irradiator laboratory

Supports preclinical research:

  • Nanoparticles
  • Advanced biomaterials
  • Immunotherapy
  • Radiation sensitizers
  • Liquid biopsy

Herter-Sprie Nature Comm 2014, Ngwa Phys Med Biol 2012, …

Vascular Modulation with Nanoparticles and Radiation

Ross Berbeco, PhD

Vascular-targeted high Z nanoparticles

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Clinical radiation therapy

Tumor vascular disruption

Improved survival

Kunjachan ACS Nano (Accepted), Kunjachan Nano Letters 2015, Berbeco IJROBP 2011,…

Funding: NIH/NCI R21, NIH/NCI R03 , JCRT Foundation,…

Technology Developments for Liquid Biopsy of Cancer

G. Mike Makrigiorgos, PhD

Goal: Eliminate “normal” DNA and detect mutated DNA and minimal residual disease in blood

Novel PCR-based enrichment techniques:

CoLD-PCR (Li Nature Medicine 2008)

NCI Link: https://imat.cancer.gov/about-imat/outputs-and-achievements/individual-technologies-and-platforms/cold-pcr-technology

Ice-CoLD-PCR (Milbury Nucleic Acid Res 2010)

NaME-PrO (Song Nucleic Acid Res 2016; Ladas Nucleic Acid Res 2018)

Funding: NIH/NCI R33 CA217652; NIH/NCI R01 CA221874; Bridge Foundation; and IMAT Program of the NCI, 1998-2018

Smart Radiotherapy Biomaterials

Wil Ngwa, PhD

Ngwa IJROBP 2017, Boateng BJR 2017, Sinha IJROBP 2015, …

Funding: R01CA239042-01, NIH/NCI K01CA172478, JCRT Foundation Grant, Brigham Research Institute, etc.

Nanoscale Radiation Transport for GNP+RT and other Apps

Piotr Zygmanski, PhD

High spatial resolution (nm-mm) ultrafast (s) with full electromagnetic coupling

High precision calculations of nanodosimetry

Gadou Nanomedicine 2018, Gadou Nanomedicine 2017, Zygmanski BJR 2016,…

Hybrid Nanoparticles for MR-guided Radiation Therapy

Ross Berbeco, PhD

Novel nanoparticles for MRI contrast and radiation dose enhancement

Gd-only and Bi-Gd nanoparticles

Preclinical work in Boston

Phase 1 clinical trial finishing in France

Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …

Funding: JCRT Foundation Grant, Brigham Research Institute

Leveraging the Abscopal Effect

Wil Ngwa, PhD

Ngwa Nature Rev Cancer 2018, Ngwa Front Oncol 2017, Hao Phys Med Biol 2016, …

Funding: NIH/NCI R21CA205094, JCRT Foundation Grant

Drug Eluting Spacers to Improve Brachytherapy

Robert Cormack, PhD

Detappe Nano Letters 2017, Detappe J Control Release 2016, Detappe Sci Rep 2016, …

Funding: JCRT Foundation Grant, Brigham Research Institute

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